UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Mild acute inflammatory stimulation induces transient negative mood

Strike, PC; Wardle, J; Steptoe, A; (2004) Mild acute inflammatory stimulation induces transient negative mood. J PSYCHOSOM RES , 57 (2) 189 - 194. 10.1016/S0022-3999(03)00569-5.

Full text not available from this repository.

Abstract

Objective: This study aims to assess the mood changes induced by mild acute inflammatory stimulation (typhoid vaccination). Methods: Using a double blind study design, 26 healthy volunteers underwent baseline assessments of mood, financial strain and work stress and were randomised to injection of Salmonella typhi vaccine or placebo injection. Mood, symptoms and body temperature was assessed by a modified version of the Profile of Mood States at 1, 2, 3, 4, 6 and 8 It post injection. Results: Typhoid vaccination induces no increases in physical symptoms or temperature. Mood improved over the day in the placebo but not in the vaccine condition. Negative changes in mood following injection were correlated with chronic stress (financial strain) in the vaccination condition (r = -.65, P <.025). Conclusion: A mild acute inflammatory stimulus induces transient negative mood, and responses were modulated by chronic stress. Implications for depressed mood in physical illness arc discussed. (C) 2004 Elsevier Inc. All rights reserved.

Type: Article
Title: Mild acute inflammatory stimulation induces transient negative mood
DOI: 10.1016/S0022-3999(03)00569-5
Keywords: inflammation, cytokines, chronic stress, mood, financial, vaccination, INDUCED SICKNESS BEHAVIOR, PSYCHOLOGICAL STRESS, DEPRESSIVE SYMPTOMS, CANCER-PATIENTS, SOCIOECONOMIC-STATUS, CYTOKINE PRODUCTION, INTERFERON-ALPHA, WHITEHALL-II, COMMON COLD, HUMANS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/111517
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item