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A role for hairy1 in regulating chick limb bud growth

Vasiliauskas, D; Laufer, E; Stern, CD; (2003) A role for hairy1 in regulating chick limb bud growth. DEV BIOL , 262 (1) 94 - 106. 10.1016/S0012-1606(03)00360-9.

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Abstract

Limb growth in higher vertebrate embryos is initially due to the outgrowth of limb buds and later continues as a result of elongation of the skeletal elements. The distal limb mesenchyme is crucial for limb bud outgrowth. Members of the Hairy/Enhancer of Split family of DNA binding transcriptional repressors can be effectors of Notch signaling and often act to maintain cell populations in an undifferentiated, proliferating state, properties predicted for the distal limb mesenchyme. We find that a member of this family, c-hairy1, is expressed in this region and that two alternatively spliced isoforms, c-hairy1A and c-hairy]B, of this gene are produced, predicting proteins that differ in their basic, DNA binding, domains. Viral misexpression of c-hairy]A causes a reduction in size of the limb and shortened skeletal elements, without affecting the chondrocyte differentiation program. Misexpression of c-hairy1B leads to a significantly lesser shortening of the bones, implying functional differences between the two isoforms. We conclude that c-hairyl regulates the size of the limb, suggesting a role for Notch signaling in the distal mesenchyme. (C) 2003 Elsevier Inc. All rights reserved.

Type: Article
Title: A role for hairy1 in regulating chick limb bud growth
DOI: 10.1016/S0012-1606(03)00360-9
Keywords: APICAL ECTODERMAL RIDGE, MAMMALIAN NEURONAL DIFFERENTIATION, DOMAIN-DNA COMPLEX, TRANSCRIPTION FACTORS, PRESOMITIC MESODERM, VERTEBRATE SEGMENTATION, POSITIONAL INFORMATION, EXPRESSION PATTERNS, CHROMOSOMAL LOCUS, CRYSTAL-STRUCTURE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/111424
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