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PDGF INCREASES THE EXPRESSION OF FOS AND JUN IN NEWLY FORMED OLIGODENDROCYTES THAT HAVE BECOME RESISTANT TO THE MITOGENIC EFFECT OF PDGF

HART, IK; RICHARDSON, WD; RAFF, MC; (1992) PDGF INCREASES THE EXPRESSION OF FOS AND JUN IN NEWLY FORMED OLIGODENDROCYTES THAT HAVE BECOME RESISTANT TO THE MITOGENIC EFFECT OF PDGF. GLIA , 6 (4) 310 - 313.

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Abstract

Bipotential glial (O-2A) progenitor cells give rise to oligodendrocytes on a predictable schedule in the developing rat optic nerve. The loss of mitotic responsiveness to platelet-derived growth factor (PDGF) that is seen when O-2A progenitor cells initially differentiate into oligodendrocytes seems to reflect blocks or deficiencies downstream to some of the early intracellular signalling events induced by PDGF. Here we show that PDGF increases the expression of the Fos and Jun nuclear proteins in newly formed oligodendrocytes in vitro, suggesting that at least one intracellular signalling pathway to the nucleus is activated by PDGF in these cells even though they do not synthesize DNA in response to PDGF.

Type: Article
Title: PDGF INCREASES THE EXPRESSION OF FOS AND JUN IN NEWLY FORMED OLIGODENDROCYTES THAT HAVE BECOME RESISTANT TO THE MITOGENIC EFFECT OF PDGF
Keywords: RAT OPTIC NERVE, O-2A PROGENITOR CELL, OLIGODENDROCYTE, IMMEDIATE-EARLY GENES, TYPE-2 ASTROCYTE DEVELOPMENT, GLIAL PROGENITOR-CELL, RAT OPTIC-NERVE, GROWTH-FACTOR, C-FOS, MONOCLONAL-ANTIBODY, PROTEIN, CULTURE, AP-1, DIFFERENTIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/109988
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