Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression.
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It is widely believed that cell-size checkpoints help to coordinate cell growth and cell-cycle progression, so that proliferating eukaryotic cells maintain their size. There is strong evidence for such size checkpoints in yeasts, which maintain a constant cell-size distribution as they proliferate, even though large yeast cells grow faster than small yeast cells. Moreover, when yeast cells are shifted to better or worse nutrient conditions, they alter their size threshold within one cell cycle. Populations of mammalian cells can also maintain a constant size distribution as they proliferate, but it is not known whether this depends on cell-size checkpoints.
|Title:||Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression.|
|Open access status:||An open access publication|
|Keywords:||Animals, Cell Cycle, Cell Growth Processes, Cell Size, Cells, Cultured, Culture Media, Growth Substances, Protein Biosynthesis, Proteins, Rats, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Schwann Cells, Sciatic Nerve|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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