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Effects of thyroid hormone on embryonic oligodendrocyte precursor call development in vivo and in vitro

Ahlgren, SC; Wallace, H; Bishop, J; Neophytou, C; Raff, MC; (1997) Effects of thyroid hormone on embryonic oligodendrocyte precursor call development in vivo and in vitro. MOL CELL NEUROSCI , 9 (5-6) 420 - 432.

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Abstract

The oligodendrocyte precursor cell divides a limited number of times before terminal differentiation. The timing of differentiation depends on both intracellular mechanisms and extracellular signals, including mitogens that stimulate proliferation and signals such as thyroid hormone (TH) and retinoic acid (RA) that help trigger the cells to stop dividing and differentiate. We show here that, both ira vivo and in vitro, TH is required for the normal development of rodent optic nerve oligodendrocytes, although in its absence some oligodendrocyte development still occurs, perhaps promoted by signals from axons. We also demonstrate that TH from both mother and pup plays a part in oligodendrocyte development in vivo. Finally, we show that precursors in embryonic nerve cultures differ from those in postnatal cultures in two ways: they respond much better Po TH than to RA, and they respond more slowly to TH, suggesting that oligodendrocyte precursor cells mature during their early development.

Type:Article
Title:Effects of thyroid hormone on embryonic oligodendrocyte precursor call development in vivo and in vitro
Keywords:PROTEIN GENE-EXPRESSION, ADULT TRANSGENIC MICE, RETINOIC ACID, GROWTH-FACTOR, MONOCLONAL-ANTIBODY, FOLLICLE CELLS, RAT-BRAIN, IN-VITRO, DIFFERENTIATION, SURVIVAL
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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