UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Caspase activation in the terminal differentiation of human epidermal keratinocytes

Weil, M; Raff, MC; Braga, VMM; (1999) Caspase activation in the terminal differentiation of human epidermal keratinocytes. CURR BIOL , 9 (7) 361 - 364.

Full text not available from this repository.

Abstract

The epidermis is a multilayered squamous epithelium in which dividing basal cells withdraw from the cell cycle and progressively differentiate as they are displaced toward the skin surface. Eventually, the cells lose their nucleus and other organelles to become flattened squames, which are finally shed from the surface as bags of cross-linked keratin filaments enclosed in a cornified envelope II]. Although keratinocytes can undergo apoptosis when stimulated by a variety of agents [2], it is not known whether their normal differentiation programme uses any components of the apoptotic biochemical machinery to produce the cornified cell, Differentiating keratinocytes have been reported to share some features with apoptotic cells, such as DNA fragmentation, but these features have not been seen consistently [3], Apoptosis involves an intracellular proteolytic cascade, mainly mediated by members of the caspase family of cysteine proteases, which cleave one another and various key intracellular target proteins to kill the cell neatly and quickly [4], Here, we show for the first time that caspases are activated during normal human keratinocyte differentiation and that this activation is apparently required for the normal loss of the nucleus.

Type:Article
Title:Caspase activation in the terminal differentiation of human epidermal keratinocytes
Keywords:PROGRAMMED CELL-DEATH, PROTEASES, APOPTOSIS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

Archive Staff Only: edit this record