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Studies on the generation of B lymphocytes in the mouse embryo.

Owen, JJ; Raff, MC; Cooper, MD; (1976) Studies on the generation of B lymphocytes in the mouse embryo. Eur J Immunol , 5 (7) 468 - 473. 10.1002/eji.1830050708.

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Using an organ culture technique, the development of B lymphocytes has been studied in a number of isolated embryonic hemopoietic tissues. Developing B lymphocytes were identified by cytoplasmic and surface immunofluorescence using purified class-specific antibodies and a Fab anti-immunoglobulin reagent. In fetal liver cultures these cells were further characterized for Fc and complement receptors and for the presence of mouse-specific B lymphocyte antigen. The results indicate that B lymphocytes develop independently in fetal liver and in fetal spleen; they do not develop in cultures of yolk sac and thymus. In conclusion, it is likely that B lymphocyte maturation in mammals is multifocal and is not dependent upon gastrointestinal influences as suggested previously.

Type: Article
Title: Studies on the generation of B lymphocytes in the mouse embryo.
DOI: 10.1002/eji.1830050708
Language: English
Keywords: Animals, B-Lymphocytes, Binding Sites, Cell Differentiation, Complement System Proteins, Ectogenesis, Female, Immunoglobulin Fc Fragments, Immunoglobulin mu-Chains, Isoantigens, Liver, Mice, Receptors, Antigen, B-Cell, Spleen, Thymus Gland, Vitelline Membrane
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/109860
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