Swinson, B; Jerjes, W; El-Maaytah, M; Norris, P; Hopper, C; (2006) Optical techniques in diagnosis of head and neck malignancy. ORAL ONCOL , 42 (3) 221 - 228. 10.1016/j.oraloncology.2005.05.001.
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The "gold standard" of assessing pathological changes in tissue is currently histopathology. However, the processing of biopsy material and the interpretation of the results inevitably leads to diagnostic delay and the added possibility of taking an unrepresentative sample.Recently, there has been increasing interest in the use of optical spectroscopy systems to be able to provide tissue diagnosis in real-time, non-invasively and in situ. These systems rely on the fact that the optical spectrum derived from any tissue will contain information about the histological and biochemical make up of that tissue. The technique has not only been shown to have a role in the detection of dysplasia and malignancy but also in performing guided biopsies, monitoring of haemoglobin tissue perfusion in free-flaps and therapeutic drug levels during chemo- and photodynamic therapy. The assessment of surgical margins and a role in sentinel node biopsy are also interesting developments.The obvious advantages of being able to accurately diagnose pathology without the need to remove a tissue sample diminish patient trauma as well as having financial implications. (c) 2005 Published by Elsevier Ltd.
|Title:||Optical techniques in diagnosis of head and neck malignancy|
|Keywords:||elastic scattering spectroscopy, Raman spectroscopy, fluorescence, trimodal spectroscopy, optical biopsy, oral cancer, head and neck cancer, oral dysplasia, head and neck dysplasia and non-invasive diagnostics, SQUAMOUS-CELL CARCINOMA, RAMAN-SPECTROSCOPY, ORAL-CANCER, AUTOFLUORESCENCE CHARACTERISTICS, FLUORESCENCE SPECTROSCOPY, TISSUE, MUCOSA, CLASSIFICATION, NEOPLASIA, RESECTION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Maxillofacial, Diagnostic, Medical and Surgical Sciences|
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