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Relationship between serum calcium and CA 19-9 levels in colorectal cancer

Fuszek, P; Lakatos, P; Tabak, A; Papp, J; Nagy, Z; Takacs, I; Horvath, HC; ... Speer, G; + view all (2004) Relationship between serum calcium and CA 19-9 levels in colorectal cancer. WORLD J GASTROENTERO , 10 (13) 1890 - 1892. Gold open access

Abstract

AIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.METHODS: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.CONCLUSION: Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.

Type: Article
Title: Relationship between serum calcium and CA 19-9 levels in colorectal cancer
Open access status: An open access publication
Publisher version: http://www.wjgnet.com/1007-9327/index.htm
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/108811
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