Linley, JE; Rose, K; Ooi, L; Gamper, N; (2010) Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. PFLUG ARCH EUR J PHY , 459 (5) 657 - 669. 10.1007/s00424-010-0784-6.
Full text not available from this repository.
Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.
|Title:||Understanding inflammatory pain: ion channels contributing to acute and chronic nociception|
|Keywords:||Ion channels, Inflammation, Pain, Nociception, PROTEIN-KINASE-C, PRIMARY AFFERENT NEURONS, PRIMARY SENSORY NEURONS, ROOT GANGLION NEURONS, NERVE GROWTH-FACTOR, POTENTIAL VANILLOID SUBFAMILY-1, COMPLETE FREUNDS-ADJUVANT, DELTA-OPIOID-RECEPTOR, CAPSAICIN-RECEPTOR, NEUROPATHIC PAIN|
Archive Staff Only: edit this record