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DERMATAN SULFATE IN HEMODIALYSIS

LANE, DA; RYAN, K; IRELAND, H; CURTIS, JR; NURMOHAMED, MT; KREDIET, RT; ... TENCATE, JW; + view all (1992) DERMATAN SULFATE IN HEMODIALYSIS. LANCET , 339 (8789) 334 - 335.

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Abstract

Experimental work suggests that dermatan sulphate has potential as an antithrombotic agent: it can inhibit venous thrombi yet has less effect upon bleeding than heparin. While heparin functions as an anticoagulant primarily by its ability to accelerate the action of the plasma protein inhibitor antithrombin III, dermatan sulphate acts selectively through a structurally related inhibitor, heparin co-factor II, to inhibit thrombin. We have done a series of dose-finding studies of the use of dermatan sulphate as an anticoagulant/antithrombotic agent in patients on maintenance haemodialysis. Dermatan sulphate proved to be an effective anticoagulant in this setting.

Type:Article
Title:DERMATAN SULFATE IN HEMODIALYSIS
Keywords:HEPARIN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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