Lane, DA; Ireland, H; Tew, CJ; Flynn, A; Curtis, JR; (1988) Equivalent effective doses of heparin and low molecular weight heparin(oid)s in haemodialysis for chronic renal failure. Acta Chir Scand Suppl , 543 101 - 104.
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In an attempt to provide an objective means of comparing the anticoagulant action of heparin with those of newly developed low MW heparin-like anticoagulants we have utilized the fibrinpeptide A assay as a method of determining fibrin formation during haemodialysis. In vivo suppression of FPA levels by increasing doses of administered anticoagulant enables equivalent effective doses of anticoagulants to be determined without making prior assumptions about which ex vivo activities of these compounds are responsible. In this communication we summarize results of studies with heparin and three low MW heparin(oid)s.
|Title:||Equivalent effective doses of heparin and low molecular weight heparin(oid)s in haemodialysis for chronic renal failure.|
|Keywords:||Blood Coagulation, Fibrinopeptide A, Heparin, Heparin, Low-Molecular-Weight, Humans, Kidney Failure, Chronic, Renal Dialysis|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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