UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Directed search for thrombomodulin gene mutations

Ireland, H; Kyriakoulis, K; Kunz, G; Lane, DA; (1996) Directed search for thrombomodulin gene mutations. HAEMOSTASIS , 26 227 - 232.

Full text not available from this repository.

Abstract

Thrombomodulin is a principle thrombin receptor located on the vascular endothelium. Thrombomodulin alters the specificity of thrombin, redirecting its procoagulant function to an anticoagulant function by making it a more efficient activator of protein C. While mutation of the genes of other components of this anticoagulant mechanism, protein C, protein S and factor V, is known to predispose towards venous thromboembolism, there are only a few reports of the investigation of thrombomodulin gene mutation. We present the design and evaluation of a strategy to investigate thrombomodulin gene mutation in arterial and venous thrombosis.

Type:Article
Title:Directed search for thrombomodulin gene mutations
Location:MONTPELLIER, FRANCE
Keywords:thrombomodulin, venous thrombosis, arterial thrombosis, myocardial infarction, PROTEIN-C, THROMBOEMBOLIC-DISEASE, THROMBIN, CDNA, ACTIVATION, COFACTOR, RECEPTOR
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

Archive Staff Only: edit this record