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Directed search for thrombomodulin gene mutations

Ireland, H; Kyriakoulis, K; Kunz, G; Lane, DA; (1996) Directed search for thrombomodulin gene mutations. HAEMOSTASIS , 26 227 - 232.

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Thrombomodulin is a principle thrombin receptor located on the vascular endothelium. Thrombomodulin alters the specificity of thrombin, redirecting its procoagulant function to an anticoagulant function by making it a more efficient activator of protein C. While mutation of the genes of other components of this anticoagulant mechanism, protein C, protein S and factor V, is known to predispose towards venous thromboembolism, there are only a few reports of the investigation of thrombomodulin gene mutation. We present the design and evaluation of a strategy to investigate thrombomodulin gene mutation in arterial and venous thrombosis.

Type: Article
Title: Directed search for thrombomodulin gene mutations
Keywords: thrombomodulin, venous thrombosis, arterial thrombosis, myocardial infarction, PROTEIN-C, THROMBOEMBOLIC-DISEASE, THROMBIN, CDNA, ACTIVATION, COFACTOR, RECEPTOR
URI: http://discovery.ucl.ac.uk/id/eprint/107071
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