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The retinoblastoma gene (rbl) in acute myeloid leukaemia: Analysis of gene rearrangements, protein expression and comparison of disease outcome

Jamal, R; Gale, RE; Thomas, NSB; Wheatley, K; Linch, DC; (1996) The retinoblastoma gene (rbl) in acute myeloid leukaemia: Analysis of gene rearrangements, protein expression and comparison of disease outcome. BRIT J HAEMATOL , 94 (2) 342 - 351.

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Abstract

The occurrence of retinoblastoma gene abnormalities in a large subset of various malignancies suggests an important role for this tumour suppressor gene in carcinogenesis, but this varies considerably from one tumour type to another and results in patients with acute myeloid leukaemia (AML) have been controversial. We analysed 106 AML patients and 18 normal controls for RB1 gene rearrangements and 86 AML patients for RE protein (pRB) expression. Southern blot analysis detected no gross gene rearrangements, but several restriction enzyme polymorphisms were observed. By Western blot analysis, 20 patients (23%) had no detectable PRE protein and seven (8%) had truncated pRB bands. Discordance between the DNA and protein data suggests that there may be minor deletions and point mutations in the RB1 gene or abnormalities in the proteins regulating the expression of pRB. No significant differences in the frequency of attainment of complete remission or length of survival were observed between patients with normal and abnormal pRB.

Type: Article
Title: The retinoblastoma gene (rbl) in acute myeloid leukaemia: Analysis of gene rearrangements, protein expression and comparison of disease outcome
Keywords: RB1, pRB, AML, rearrangements, survival, ACUTE MYELOGENOUS LEUKEMIA, SUSCEPTIBILITY GENE, CELL-CYCLE, INACTIVATION, PRODUCT, CARCINOMA, MUTATIONS, ABNORMALITIES, DELETION, SEQUENCE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/107010
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