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Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine

Blann, AD; Williams, NR; Lip, GYH; Rajput-Williams, J; Howard, AN; (2002) Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine. BLOOD COAGUL FIBRIN , 13 (7) 647 - 651.

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Abstract

Long-term moderate alcohol use is associated with a better cardiovascular risk profile than total abstinence, although the short-term effect of a bolus of alcohol is unclear. The hypothesis tested in this study was that an acute bolus of alcohol would adversely affect the endothelium and platelets. Blood was taken before and 4 It after the ingestion of red or white wine by nine volunteers per group, and by 11 control water-only drinkers at the same time points. Plasma was obtained and markers of platelet activity (beta-thromboglobulin and soluble P selectin) and endothelial cell function (von Willebrand factor and soluble thrombomodulin) measured by enzyme-linked immunosorbent assay. The only marker to change significantly was beta-thromboglobulin, which increased from a median of 10 ng/ml (interquartile range, 8.5-15) before drinking red wine to 16 ng/ml (interquartile range, 14-20) 4 h later (P = 0.0067). We conclude that an acute bolus of red wine, but not white wine, activates platelets but has no substantial effect on the endothelium. (C) 2002 Lippincott Williams Wilkins.

Type: Article
Title: Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine
Keywords: wine, polyphenols, platelets, endothelium, von Willebrand factor, soluble thrombomodulin, soluble P selectin, beta-thromboglobulin, MODERATE ALCOHOL-CONSUMPTION, CORONARY HEART-DISEASE, VON-WILLEBRAND-FACTOR, PLASMINOGEN-ACTIVATOR, STROKE, RISK, ATHEROSCLEROSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: http://discovery.ucl.ac.uk/id/eprint/106989
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