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Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC

Horton, R; Niblett, D; Milne, S; Palmer, S; Tubby, B; Trowsdale, J; Beck, S; (1998) Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC. J MOL BIOL , 282 (1) 71 - 97.

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Abstract

Comparison of genomic sequences flanking the HLA-DQB1 locus in the human MHC class II region reveals local sequence variation of up to 10%, which is the highest level of sequence variation found in the human genome so far. The variation is haplotype-specific and extends far beyond the transcriptional unit of the DQB1 gene, suggesting hitch-hiking along with functionally selected alleles as the most Likely mechanism. All major insertions/deletions (indels) were found to be of retroviral origin and in the immediate upstream region of DQB1. Possible cis-acting effects of these indels on the transcriptional regulation of DQB1 are discussed. (C) 1998 Academic Press.

Type: Article
Title: Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC
Keywords: DNA sequencing, DNA variation, human endogenous retrovirus (HERV), major histocompatibility complex (MHC), MHC haplotypes, MAJOR HISTOCOMPATIBILITY COMPLEX, LONG TERMINAL REPEATS, DNA, ORGANIZATION, GENE, DQ, SELECTION, CLONING, FAMILY, POLYMORPHISM
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: http://discovery.ucl.ac.uk/id/eprint/106498
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