Horton, R and Wilming, L and Rand, V and Lovering, RC and Bruford, EA and Khodiyar, VK and Lush, MJ and Povey, S and Talbot, CC and WrighO, MW and Wain, HM and Trowsdale, J and Ziegler, A and Beck, S (2004) Gene map of the extended human MHC. NAT REV GENET , 5 (12) 889 - 899. 10.1038/nrg1489.
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Abstract
The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.
| Type: | Article |
|---|---|
| Title: | Gene map of the extended human MHC |
| DOI: | 10.1038/nrg1489 |
| Keywords: | MAJOR HISTOCOMPATIBILITY COMPLEX, IMMUNITY-RELATED GENES, CLASS-I REGION, HEREDITARY HEMOCHROMATOSIS, LINKAGE DISEQUILIBRIUM, COMPARATIVE GENOMICS, ANOPHELES-GAMBIAE, RECEPTOR GENES, RNA GENES, DISEASE |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
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