POWIS, SH and MOCKRIDGE, I and KELLY, A and KERR, LA and GLYNNE, R and GILEADI, U and BECK, S and TROWSDALE, J (1992) POLYMORPHISM IN A 2ND ABC TRANSPORTER GENE LOCATED WITHIN THE CLASS-II REGION OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX. P NATL ACAD SCI USA , 89 (4) 1463 - 1467.
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Abstract
Recent studies have identified genes within the major histocompatibility complex (MHC) that may play a role in presentation of antigenic peptides to T cells. We have previously described RING4, a gene within the human MHC class II region that has sequence homology with members of the ABC ("ATP-binding cassette") transporter superfamily. We now report the nucleotide sequence of RING11, a second ABC transporter gene located approximately 7 kilobases telomeric to RING4. RING11 is gamma-interferon inducible, a property shared with other genes involved in antigen presentation. Comparison between the amino acid sequences of RING11 and RING4 reveals strong homology. We propose that they form a heterodimer that transports peptides from the cytoplasm into the endoplasmic reticulum. We have identified two RING11 alleles, which differ in the length of their derived protein sequence by 17 amino acids. The more common of these alleles is present in a Caucasoid population at a frequency of 79%.
| Type: | Article |
|---|---|
| Title: | POLYMORPHISM IN A 2ND ABC TRANSPORTER GENE LOCATED WITHIN THE CLASS-II REGION OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX |
| Keywords: | HLA, ANTIGEN PROCESSING, NUCLEOTIDE-BINDING FOLD, RESISTANT HUMAN-CELLS, MHC CLASS-II, SALMONELLA-TYPHIMURIUM, CYSTIC-FIBROSIS, OLIGOPEPTIDE PERMEASE, MULTIDRUG RESISTANCE, BACTERIAL TRANSPORT, MEMBRANE-PROTEIN, ESCHERICHIA-COLI |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology |
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