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DEXAMETHASONE PROMOTES ULCER PLUGGING IN EXPERIMENTAL ENTERITIS

ANTHONY, A; DHILLON, AP; SIM, R; POUNDER, RE; WAKEFIELD, AJ; (1994) DEXAMETHASONE PROMOTES ULCER PLUGGING IN EXPERIMENTAL ENTERITIS. ALIMENT PHARM THERAP , 8 (6) 597 - 602.

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Abstract

Aim: We investigated the effect of dexamethasone on indomethacin-induced ulceration in the rat.Methods: Groups of four rats received oral indomethacin (15 mg/kg) and the jejunal mucosa was examined 24 h later for mucosal ulceration, Three of the groups received oral dexamethasone (1, 3 and 6 mg/kg) 0.5 h prior to indomethacin, while the fourth received vehicle. Haematological evaluation was performed and ulcers were assessed both histologically and immunohistochemically.Results: Indomethacin caused multifocal jejunal ulceration that was reduced only by the highest dose of dexamethasone (6 mg/kg), Indomethacin caused a significant fall in the blood haemoglobin concentration that was prevented by dexamethasone at all doses, The ulcers induced by indomethacin alone were deep, punched-out and haemorrhagic while the ulcers arising in rats pre-treated with dexamethasone (all doses) were ''plugged'' by a white fibrino-purulent exudate. Histologically, the dexamethasone ulcer exudate was composed of bacteria, fibrin, mucus and a significant increase in the numbers of neutrophils. Dexamethasone alone had no significant pathological effect on the small intestine.Conclusions: We report the observation that dexamethasone at high doses inhibits indomethacin-induced jejunal ulceration in the rat while at low doses it promotes ''plugging'' of ulcers with bacteria, fibrin, mucus and neutrophils that probably reduces haemorrhage from the ulcer base.

Type: Article
Title: DEXAMETHASONE PROMOTES ULCER PLUGGING IN EXPERIMENTAL ENTERITIS
Keywords: INFLAMMATORY BOWEL-DISEASE, INDUCED INTESTINAL LESIONS, INDOMETHACIN, RAT, MODEL
URI: http://discovery.ucl.ac.uk/id/eprint/1058000
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