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The prognostic influence of bcl-2 in malignant glioma

McDonald, F.E.; Ironside, J.W.; Gregor, A.; Wyatt, B.; Stewart, M.; Rye, R.; Adams, J.; (2002) The prognostic influence of bcl-2 in malignant glioma. British Journal of Cancer , 86 pp. 1899-1904. 10.1038/sj.bjc.6600217.

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The bcl-2 gene is one of a complex group of genes which control programmed cell death. Bcl-2 acts to extend cell survival by blocking apoptosis, and thereby may influence tumour prognosis. This study of 187 high grade gliomas reviews clinicopathological prognostic features and the relationship to bcl-2 expression. Bcl-2 immunostaining was assessed in 159 specimens from these patients, by scoring systems of 0 to 3 for intensity of scoring and proportion of cells staining. Age, histology, pre- and post-operative performance status were found to be strongly predictive of survival (log rank test P<0.0001). The type of surgery performed did not influence survival in this group of patients. The expression of bcl-2 had a significant relationship with survival (univariate Cox model P=0.0302, hazard ratio 0.8, 95% confidence interval 0.65-0.98), with increased staining associated with improved survival. Multivariate analysis showed performance status, histology and proportion of cells staining for bcl-2 to be independently predictive of survival. Bcl-2 staining was not related to histological grade of tumours.

Type: Article
Title: The prognostic influence of bcl-2 in malignant glioma
DOI: 10.1038/sj.bjc.6600217
Publisher version: http://dx.doi.org/10.1038/sj.bjc.6600217
Language: English
Keywords: high grade glioma, bcl-2, multivariate analysis
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > CHIME
URI: http://discovery.ucl.ac.uk/id/eprint/1054
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