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Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later

Uhlhaas, PJ; Millard, I; Muetzelfeldt, L; Curran, HV; Morgan, CJA; (2007) Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later. J PSYCHOPHARMACOL , 21 (3) 347 - 352. 10.1177/0269881107077739.

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Abstract

N-methyl-D-aspartate (NMDA)-receptor antagonists such as ketamine can induce transient schizophrenia-like symptoms and cognitive dysfunctions in healthy volunteers similar to those observed in patients with schizophrenia. Perceptual organization deficits have been documented in schizophrenia and are thought to be related to some symptoms associated with the illness. The current study was designed to determine whether people who repeatedly self-administer ketamine would also show deficits in perceptual organization. Using a psychophysically well-controlled measure of contour integration, we compared a group of recreational users (n = 16) to a group of poty-drug using controls (n = 16). Contour integration performance was measured on the night of drug use and 3 days later when drug free. The results showed that on the night of drug use, ketamine produced a dysfunction in contour integration however, this was not present 3 days later when drug free. Levels of dissociation were also higher in ketamine users only on the night of drug use. These preliminary data provide some support for the role of NMDA-receptor hypofunctioning in dysfunctional coordination of cognitive activity.

Type: Article
Title: Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days later
DOI: 10.1177/0269881107077739
Keywords: NMDA, ketamine, drug abuse, schizophrenia, chronic effects, perceptual organization, HEALTHY-VOLUNTEERS, CHRONIC-SCHIZOPHRENIA, PSYCHOTIC SYMPTOMS, VISUAL CONTEXT, PHENCYCLIDINE, MODELS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/105086
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