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Verbal fluency facilitated by the cholinergic blocker, scopolamine

Pompeia, S; Rusted, JM; Curran, HV; (2002) Verbal fluency facilitated by the cholinergic blocker, scopolamine. HUM PSYCHOPHARM CLIN , 17 (1) 51 - 59.

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Abstract

This study was designed to explore putative facilitatory effects of low doses of scopolamine (SP) on phonemic (letter) and semantic (category) verbal fluency. A double-blind, parallel-group design was used with 36 subjects who completed a test battery before and 2 h after 0.6 mg or 1.2 mg of SP or placebo. Fluency measures included total number of words generated, clustering (the production of words within semantic or phonemic subcategories) and switching (the ability to shift efficiently to new subcategories). Low doses of scopolamine increased phonemic fluency, as has been shown previously. Semantic fluency was not increased by SP, although subjects treated with 1.2 mg of SP generated higher-frequency words. SP did not affect clustering or switching. It is suggested that phonemic and semantic fluency reflect distinct cognitive processes. Copyright (C) 2002 John Wiley Sons, Ltd.

Type: Article
Title: Verbal fluency facilitated by the cholinergic blocker, scopolamine
Keywords: scopolamine, anticholinergic, muscarinic antagonist, verbal fluency, semantic memory, clustering, switches, ALZHEIMERS-DISEASE PATIENTS, HUMAN-MEMORY, DEMENTIA, DEFICITS, HUMANS, MODEL, AGE, SCHIZOPHRENIA, SENSITIVITY, VOLUNTEERS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/105059
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