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Anti-beta 2-glycoprotein I, anti-prothrombin and anticardiolipin antibodies in a longitudinal study of patients with systemic lupus erythematosus and the antiphospholipid syndrome

Inanc, M; Donohoe, S; Ravirajan, CT; Radway-Bright, EL; Mackie, I; Machin, S; Isenberg, DA; (1998) Anti-beta 2-glycoprotein I, anti-prothrombin and anticardiolipin antibodies in a longitudinal study of patients with systemic lupus erythematosus and the antiphospholipid syndrome. BRIT J RHEUMATOL , 37 (10) 1089 - 1094.

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Abstract

Objective. To determine anti-beta 2 glycoprotein-I (anti-beta 2GPI) and anti-prothrombin (anti-ProT) antibody levels, and the IgG subclass distribution of anti-beta 2GPI antibodies, in serial samples from patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) having initial or recurrent thrombotic/neurological (T/N) events during the study period. To investigate the correlations between these antibodies and beta 2GPI antigen, anticardiolipin antibody (aCL), anti-double-stranded (ds) DNA, C3 levels and disease activity.Methods. Fifty serum samples were identified from seven patients with SLE who had, had T/N events during the follow-up from a cohort under long-term follow-up. IgG anti-beta 2GPI, anti-ProT, aCL, IgG subclasses of anti-beta 2GPI and beta 2GPI antigen levels were determined by ELISA. Corresponding disease activity [British Isles Lupus Assessment Group (BILAG)], anti-dsDNA and C3 levels were compared.Results. IgG anti-beta 2GPI antibody levels were elevated in six of the patients before anti after the T/N events with less marked fluctuations than aCL antibody levels. The predominant subclass of anti-beta 2GPI antibodies was IgG2 before and after the T/N events. IgG anti-ProT antibodies were negative in all cases. There was a significant but weak correlation between anti-beta 2GPI and aCL antibodies. No correlation was found between disease activity-and IgG anli-beta 2GPI antibody and beta 2GPI antigen levels. There were fluctuations in beta 2GPI antigen levels and a trend to increase after T/N events was observed in some patients.Conclusion. Most of the patients with a T/N event during the study period had IgG anti-beta 2GPI, but not IgG anti-ProT antibodies. Many Ige aCl-negative samples were found to have IgG anti-beta 2GPI activity during the follow-up period. The predominant subclass of IgG anti-beta 2GPI was IgG2, which may have importance in the pathogenesis of APS. beta 2GPI antigen levels were found to be increased in some patients with SLE after T/N events. Ige anti-beta 2GPI antibodies may be used as an adjunctive marker of future T/N events in patients with SLE and APS with aCL antibodies and lupus anticoagulant.

Type: Article
Title: Anti-beta 2-glycoprotein I, anti-prothrombin and anticardiolipin antibodies in a longitudinal study of patients with systemic lupus erythematosus and the antiphospholipid syndrome
Keywords: systemic lupus erythematosus, antiphospholipid syndrome, anti-beta 2 glycoprotein-I, anti-prothrombin, CLINICAL MANIFESTATIONS, GLYCOPROTEIN-I, BETA-2-GLYCOPROTEIN-I, ELISA, BETA(2)-GLYCOPROTEIN-I, AUTOANTIBODIES, SPECIFICITY, ASSAY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/104806
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