UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

mTORbeta splicing isoform promotes cell proliferation and tumorigenesis

Panasyuk, G; Nemazanyy, I; Zhyvoloup, A; Filonenko, V; Davies, D; Robson, M; Pedley, RB; ... Gout, I; + view all (2009) mTORbeta splicing isoform promotes cell proliferation and tumorigenesis. J.Biol.Chem. , 284 (45) pp. 30807-30814.

Full text not available from this repository.

Abstract

The mTOR (mammalian target of rapamycin) promotes growth in response to nutrients and growth factors and is deregulated in numerous pathologies, including cancer. The mechanisms by which mTOR senses and regulates energy metabolism and cell growth are relatively well understood, whereas the molecular events underlining how it mediates survival and proliferation remain to be elucidated. Here, we describe the existence of the mTOR splicing isoform, TOR beta, which, in contrast to the full-length protein (mTOR alpha), has the potential to regulate the G(1) phase of the cell cycle and to stimulate cell proliferation. mTOR beta is an active protein kinase that mediates downstream signaling through complexing with Rictor and Raptor proteins. Remarkably, overexpression of mTOR beta transforms immortal cells and is tumorigenic in nude mice and therefore could be a proto-oncogene

Type: Article
Title: mTORbeta splicing isoform promotes cell proliferation and tumorigenesis
Additional information: DA - 20091102 IS - 1083-351X (Electronic) IS - 0021-9258 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't RN - 0 (Protein Isoforms) RN - EC 2.7.- (Protein Kinases) RN - EC 2.7.1.- (mTOR protein) SB - IM
Keywords: Animals, Cell Cycle, Cell Line, Cell Proliferation, Cell Transformation,Neoplastic, Humans, Mice, Mice,Nude, Protein Isoforms, genetics, metabolism, Protein Kinases, Protein Transport, RNA Splicing
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/104275
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item