UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

CoA Synthase is in complex with p85 alpha PI3K and affects PI3K signaling pathway

Breus, O; Panasyuk, G; Gout, IT; Filonenko, V; Nemazanyy, I; (2009) CoA Synthase is in complex with p85 alpha PI3K and affects PI3K signaling pathway. BIOCHEM BIOPH RES CO , 385 (4) 581 - 585. 10.1016/j.bbrc.2009.05.102.

Full text not available from this repository.

Abstract

The complex interplay between cellular signaling and metabolism in eukaryotic cells just start to emerge. Coenzyme A (CoA) and its derivatives play a key role in cell metabolism and also participate in regulatory processes. CoA Synthase (CoASy) is a mitochondria-associated enzyme which mediates two final stages of de novo CoA biosynthesis. Here, we report that CoASy is involved in signaling events in the cell and forms a functional complex with p85 alpha PI3K in vivo. Importantly, observed interaction of endogenous CoASy and p85 alpha PI3K is regulated in a growth factor dependent manner. Surprisingly, both catalytic p110 alpha and regulatory p85 alpha subunits of PI3K were detected in mitochondrial fraction where mitochondria-localized p85aPI3K was found in complex with CoASy. Unexpectedly, significant changes of PI3K signaling pathway activity were observed in experiments with siRNA-mediated CoASy knockdown pointing on the role of CoA biosynthetic pathway in signal transduction. (c) 2009 Elsevier Inc. All rights reserved.

Type: Article
Title: CoA Synthase is in complex with p85 alpha PI3K and affects PI3K signaling pathway
DOI: 10.1016/j.bbrc.2009.05.102
Keywords: Coenzyme A, CoASy, PI3K, p85 alpha PI3K, Metabolism, COENZYME-A, CELL-GROWTH, BIOSYNTHESIS, METABOLISM, ACTIVATION, EXPRESSION, CANCER, ENZYME, LINK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/104242
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item