Boychyn, M and Yim, SSS and Bulmer, M and More, J and Bracewell, DG and Hoare, M (2004) Performance prediction of industrial centrifuges using scale-down models. BIOPROC BIOSYST ENG , 26 (6) 385 - 391. 10.1007/s00449-003-0328-y.
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Abstract
Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge (TM)) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.
| Type: | Article |
|---|---|
| Title: | Performance prediction of industrial centrifuges using scale-down models |
| DOI: | 10.1007/s00449-003-0328-y |
| Keywords: | centrifugation, scale-down, shear, clarification, STACK CENTRIFUGE, FLOW INTENSITY, RECOVERY |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering |
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