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Performance prediction of industrial centrifuges using scale-down models

Boychyn, M; Yim, SSS; Bulmer, M; More, J; Bracewell, DG; Hoare, M; (2004) Performance prediction of industrial centrifuges using scale-down models. BIOPROC BIOSYST ENG , 26 (6) 385 - 391. 10.1007/s00449-003-0328-y.

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Abstract

Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge (TM)) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.

Type:Article
Title:Performance prediction of industrial centrifuges using scale-down models
DOI:10.1007/s00449-003-0328-y
Keywords:centrifugation, scale-down, shear, clarification, STACK CENTRIFUGE, FLOW INTENSITY, RECOVERY
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering

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