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Effects of Preterm Birth on Cortical Thickness Measured in Adolescence

Nagy, Z; Lagercrantz, H; Hutton, C; (2011) Effects of Preterm Birth on Cortical Thickness Measured in Adolescence. CEREB CORTEX , 21 (2) 300 - 306. 10.1093/cercor/bhq095.

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Abstract

Despite the extensive research into brain development after preterm birth, few studies have investigated its long-term effects on cortical thickness. The Stockholm Neonatal Project included infants between 1988 and 1993 with birth weight (BW) < 1500 g. Using a previously published method, cortical thickness was estimated on T-1-weighted 3D anatomical images acquired from 74 ex-preterm and 69 term-born adolescents (mean age 14.92 years). The cortex was significantly thinner in ex-preterm individuals in focal regions of the temporal and parietal cortices as indicated by voxel-wise t-tests. In addition, large regions around the central sulcus and temporal lobe as well as parts of the frontal and occipital lobes tended also to be thinner in the ex-preterm group. Although these results were not significant on voxel-wise tests, the spatially coherent arrangement of the thinning in ex-preterm individuals made it notable. When the group of ex-preterm individuals was divided by gestational age or BW, the thinning tended to be more pronounced in the anterior and posterior poles in those born nearer term or with a BW closer to 1500 g. These results support the notion that preterm birth is a risk factor for long-term development of cortical thickness.

Type: Article
Title: Effects of Preterm Birth on Cortical Thickness Measured in Adolescence
DOI: 10.1093/cercor/bhq095
Keywords: brain, cerebral cortex, cortical thickness, MRI, preterm, HUMAN CEREBRAL-CORTEX, PREMATURE-INFANTS, GRAY-MATTER, BRAIN, CHILDREN, WEIGHT, GROWTH, SEGMENTATION, MATURATION, OUTCOMES
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/103839
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