UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis.

Jeganathan, S; Ufomata, D; Hobkirk, JA; Ivanyi, L; (1987) Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis. Clin Exp Immunol , 70 (2) 316 - 321.

Full text not available from this repository.

Abstract

Immunoglobulin A antibody titres to a cytoplasmic protein extract of Candida albicans were determined by ELISA in saliva from 20 patients with oral candidosis and 21 controls. Patients had significantly increased levels of salivary IgA anti-Candida antibodies when compared with controls (P less than 0.001). Antibody levels were associated with IgA1 subclass in 90% of the patients; in contrast, IgA2 subclass was predominant in 67% of the controls. Antifungal therapy resulted in significantly decreased IgA1 titres (P less than 0.05) whilst the mean IgA2 antibody titre remained unchanged. The results indicate that Candida infection may change the subclass pattern of salivary IgA antibodies.

Type:Article
Title:Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis.
Location:ENGLAND
Language:English
Additional information:PMCID: PMC1542086
Keywords:Adult, Aged, Antibodies, Fungal, Antigens, Bacterial, Antigens, Fungal, Candida albicans, Candidiasis, Oral, Female, Humans, Immunoglobulin A, Secretory, Male, Middle Aged, Saliva
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute

Archive Staff Only: edit this record