UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Differential regulation of HLA-DQ expression by keratinocytes and Langerhans cells in normal and premalignant cervical epithelium

Mota, FF; Rayment, NB; Kanan, JH; Singer, A; Chain, BM; (1998) Differential regulation of HLA-DQ expression by keratinocytes and Langerhans cells in normal and premalignant cervical epithelium. Tissue Antigens , 52 (3) pp. 286-293. 10.1111/j.1399-0039.1998.tb03046.x.

Full text not available from this repository.

Abstract

Keratinocytes in normal ectocervix did not express major histocompatibility complex class II molecules. In low-grade intraepithelial lesions expression was confined to HLA-DR, while in high-grade disease there was expression of HLA-DR and occasional expression of HLA-DQ. HLA-DR was expressed constitutively on the majority of Langerhans cells. In contrast, few Langerhans cells expressed HLA-DQ in normal cervix, but there was a steady upregulation of the proportion expressing HLA-DQ which paralleled the severity of disease. There was no direct correlation between human papillomavirus 16 and the expression of major histocompatibility complex class II by keratinocytes and Langerhans cells. Significant upregulation of HLA-DQ by Langerhans cells is observed in high-grade intraepithelial cervical lesions, suggesting antigen-presenting cell activation in papillomavirus-related premalignant disease.

Type: Article
Title: Differential regulation of HLA-DQ expression by keratinocytes and Langerhans cells in normal and premalignant cervical epithelium
DOI: 10.1111/j.1399-0039.1998.tb03046.x
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/103373
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item