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ANTIGEN-PROCESSING AND PRESENTATION OF HUMAN RHINOVIRUS TO CD4 T-CELLS IS FACILITATED BY BINDING TO CELLULAR RECEPTORS FOR VIRUS

HASTINGS, GZ; FRANCIS, MJ; ROWLANDS, DJ; CHAIN, BM; (1993) ANTIGEN-PROCESSING AND PRESENTATION OF HUMAN RHINOVIRUS TO CD4 T-CELLS IS FACILITATED BY BINDING TO CELLULAR RECEPTORS FOR VIRUS. EUR J IMMUNOL , 23 (6) 1340 - 1345.

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Abstract

Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor-binding ability. In this study minor receptor-binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen-presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor-group HRV. Pre-treatment of HRV 1A, a minor-group virus, with HRV 1A-specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non-binding major serotype, gave no inhibition. The cell binding ability of minor-group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major-group viruses in mice.

Type: Article
Title: ANTIGEN-PROCESSING AND PRESENTATION OF HUMAN RHINOVIRUS TO CD4 T-CELLS IS FACILITATED BY BINDING TO CELLULAR RECEPTORS FOR VIRUS
Keywords: ANTIGEN PROCESSING, HUMAN RHINOVIRUS, CD4 ANTIGEN PRESENTATION, INTERFERON-GAMMA, IMMUNE-RESPONSES, DENDRITIC CELLS, POLIOVIRUS, SEROTYPES, INFECTION, ICAM-1
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/103366
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