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THE EFFECTS OF AURANOFIN ON ACTIVATION AND INTERLEUKIN-2 RELEASE FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

VINT, IAM; CHAIN, BM; FOREMAN, JC; (1993) THE EFFECTS OF AURANOFIN ON ACTIVATION AND INTERLEUKIN-2 RELEASE FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS. AGENTS ACTIONS , 40 (3-4) 209 - 214.

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Abstract

Auranofin, 30-300 nM causes a concentration-dependent potentiation of phytohaemagglutinin (PHA)induced interleukin-2 (IL-2) release from human peripheral blood mononuclear cells in culture. At concentrations of auranofin between 1 and 3 mu M, PHA-stimulated IL-2 release was inhibited, and the drug is cytotoxic at these concentrations.At concentrations of auranofin which potentiated PHA-induced IL-2 release, it had no effect on [H-3]-thymidine incorporation. Auranofin, 3 to 300 nM caused a concentration-dependent increase in the population of peripheral blood mononuclear cells bearing the IL-2 receptor (Tac positive cells). Auranofin, 300 nM caused an increase of approximately 100% in the glutathione level within the resting eels, and also increased the glutathione level in PHA-stimulated cells.

Type: Article
Title: THE EFFECTS OF AURANOFIN ON ACTIVATION AND INTERLEUKIN-2 RELEASE FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS
Keywords: PROTEIN KINASE-C, RHEUMATOID-ARTHRITIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/103363
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