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PROSTAGLANDIN-E2 (PGE2) DIFFERENTIALY REGULATES THE PRODUCTION OF IL-2 AND IL-3 BY MURINE IMMUNE T-CELLS

MARCINKIEWICZ, J; RADZISZEWSKI, W; CHAIN, BM; (1992) PROSTAGLANDIN-E2 (PGE2) DIFFERENTIALY REGULATES THE PRODUCTION OF IL-2 AND IL-3 BY MURINE IMMUNE T-CELLS. FOLIA HISTOCHEM CYTO , 30 (1) 1 - 4.

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Abstract

Eicosanoids are important mediators of inflamation, and have been shown to have potent, and usually suppressive immunoregulatory activities. In the paper, we have examined the role of prostaglandin (PGE2) production in the regulation of two cytokines, IL-2 and IL-3, which both play a key role in contact sensitivity and delayed type hypersensitivity reactions. In agreement with previous studies, we demonstrate that prostaglandins down-regulate IL-2 production in the system. Unexpectedly, however, IL-3 levels are enhanced in the presence of the prostaglandin PGE2 and conversely, are inhibited by treatment with aspirin, a potent inhibitor of prostaglandin metabolism. The implications of this result in terms of the immunoregulatory role of PGs will be discussed.

Type: Article
Title: PROSTAGLANDIN-E2 (PGE2) DIFFERENTIALY REGULATES THE PRODUCTION OF IL-2 AND IL-3 BY MURINE IMMUNE T-CELLS
Keywords: LEISHMANIASIS, EICOSANOIDS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/103324
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