Using evolutionary trees in protein secondary structure prediction and other comparative sequence analyses.
Journal of Molecular Biology
196 - 208.
Previously proposed methods for protein secondary structure prediction from multiple sequence alignments do not efficiently extract the evolutionary information that these alignments contain. The predictions of these methods are less accurate than they could be, because of their failure to consider explicitly the phylogenetic tree that relates aligned protein sequences. As an alternative, we present a hidden Markov model approach to secondary structure prediction that more fully uses the evolutionary information contained in protein sequence alignments. A representative example is presented, and, three experiments are performed that illustrate how the appropriate representation of evolutionary relatedness can improve inferences. We explain why similar improvement call be expected in other secondary structure prediction methods and indeed any comparative sequence analysis method.
|Title:||Using evolutionary trees in protein secondary structure prediction and other comparative sequence analyses|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Computer Science|
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