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High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans

Gilbey, SG; Stephenson, J; O'Halloran, DJ; Burrin, JM; Bloom, SR; (1989) High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans. Diabetes , 38 (9) pp. 1114-1116.

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Abstract

The neuropeptide galanin inhibits glucose-stimulated insulin release in dogs and rodents and has been proposed as having a role in the control of insulin release in humans. The effect of infused galanin on intravenous glucose tolerance in humans was investigated by giving an intravenous glucose tolerance test (0.5 g glucose/kg body wt) alone and with infusions of synthetic porcine galanin at high-dose levels (80 and 160 pmol.kg-1.min-1) to seven healthy male volunteers. The results showed no effect of galanin infusion on plasma glucose or serum insulin, although a rise in serum growth hormone even in the face of the intravenous glucose load confirmed the potent growth hormone-stimulating effect of galanin. These results suggest that caution should be exercised in extrapolating a physiological role for galanin in humans from the results of animal studies

Type: Article
Title: High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans
Keywords: administration & dosage, analysis, Animals, blood, Blood Glucose, Galanin, Glucose, Glucose Tolerance Test, Growth Hormone, Humans, Infusions,Intravenous, Insulin, London, Male, Neuropeptides, Peptides, pharmacology, Swine, Time Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: http://discovery.ucl.ac.uk/id/eprint/1030108
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