UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality

Concha, ML; Russell, C; Regan, JC; Tawk, M; Sidi, S; Gilmour, DT; Kapsimali, M; ... Wilson, SW; + view all (2003) Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. NEURON , 39 (3) 423 - 438.

Full text not available from this repository.

Abstract

The mechanisms that establish behavioral, cognitive, and neuroanatomical asymmetries are poorly understood. In this study, we analyze the events that regulate development of asymmetric nuclei in the dorsal forebrain. The unilateral parapineal organ has a bilateral origin, and some parapineal precursors migrate across the midline to form this left-sided nucleus. The parapineal subsequently innervates the left habenula, which derives from ventral epithalamic cells adjacent to the parapineal precursors. Ablation of cells in the left ventral epithalamus can reverse laterality in wildtype embryos and impose the direction of CNS asymmetry in embryos in which laterality is usually randomized. Unilateral modulation of Nodal activity by Lefty1 can also impose the direction of CNS laterality in embryos with bilateral expression of Nodal pathway genes. From these data, we propose that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition.

Type: Article
Title: Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality
Keywords: LEFT-RIGHT ASYMMETRY, LEFT-RIGHT AXIS, PARAPINEAL ORGAN, ZEBRAFISH DIENCEPHALON, NERVOUS-SYSTEM, PINEAL COMPLEX, FLOATING HEAD, PARIETAL EYE, BRAIN, EXPRESSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/10297
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item