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CHRONIC OPIATE AGONISTS DOWN-REGULATE PRODYNORPHIN GENE-EXPRESSION IN RAT-BRAIN

ROMUALDI, P; LESA, G; FERRI, S; (1991) CHRONIC OPIATE AGONISTS DOWN-REGULATE PRODYNORPHIN GENE-EXPRESSION IN RAT-BRAIN. BRAIN RES , 563 (1-2) 132 - 136.

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Abstract

The effects of long-term administration of opioid agonists on the regulation of prodynorphin gene expression in rat brain were investigated. Chronic intracerebroventricular treatment with the synthetic opioid agonist acting on the kappa-receptor, U-50,488H, and the classic mu-agonist morphine markedly decreased prodynorphin mRNA levels in hypothalamus, hippocampus and striatum of tolerant rats. Levels of ir-Dynorphin A remained unchanged except in two cases. Chronic exposure to opiates thus appears to induce modifications of the endogenous opioid system, as regards gene expression regulation.

Type:Article
Title:CHRONIC OPIATE AGONISTS DOWN-REGULATE PRODYNORPHIN GENE-EXPRESSION IN RAT-BRAIN
Keywords:OPIATE, TOLERANCE, GENE EXPRESSION, PRODYNORPHIN MESSENGER RNA, RAT BRAIN, CHRONIC, MORPHINE, U-50,488H, CHRONIC MORPHINE EXPOSURE, OPIOID RECEPTORS, SPINAL-CORD, TOLERANCE, INCREASES, ACID, FOS

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