ROMUALDI, P and LESA, G and DONATINI, A and BALBONI, G and TOMATIS, R and FERRI, S (1992) ALTERATIONS IN VASOACTIVE INTESTINAL POLYPEPTIDE-RELATED PEPTIDES AFTER PENTYLENETETRAZOLE-INDUCED SEIZURES IN RAT-BRAIN. EUR J PHARMACOL , 229 (2-3) 149 - 153.
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Abstract
The possible involvement of vasoactive intestinal polypeptide-related peptides in pentylenetetrazol (PTZ)-induced seizures in rats was investigated. The chemoconvulsant PTZ was administered (45 mg/kg i.p.) either acutely or chronically for three days. The detailed time course of changes in VIP-(1-28) and VIP-(22-28) was examined in several rat brain areas 5 and 20 min and 24 h after acute treatment and after three days chronic treatment. Ir-VIP levels dramatically decreased in all areas 5 min after PTZ injection, remained low after 20 min and progressively increased back to control values after 24 h and after three days of repeated treatment (except for the cortex). Chromatographic analysis of extracts prepared from PTZ-treated rats revealed a concomitant decrease in VIP-(1-28) and increase in VIP-(22-28). Thus VIP-(22-28) might be a product of the internal cleavage of the precursor VIP-(1-28) after its neuronal release; alternatively, VIP-(22-28) might be generated by post-transcriptional processing of VIP-(1-28), and thus be an 'independent' neuropeptide. The results suggest that VIP-(1-28)/VIP-(22-28)-containing neurons might be involved in PTZ-induced seizures in rat brain, and that VIP-(22-28) might play a role in these experimental seizures.
| Type: | Article |
|---|---|
| Title: | ALTERATIONS IN VASOACTIVE INTESTINAL POLYPEPTIDE-RELATED PEPTIDES AFTER PENTYLENETETRAZOLE-INDUCED SEIZURES IN RAT-BRAIN |
| Keywords: | VIP (VASOACTIVE INTESTINAL POLYPEPTIDE), VIP-(22-28), PENTYLENETETRAZOLE, SEIZURES, BRAIN (RAT), ACID-INDUCED SEIZURES, NEUROPEPTIDE-Y, IMMUNOREACTIVE SOMATOSTATIN, KINDLED RATS, VIP, MORPHINE, CORTEX, GABA, CELL |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Laboratory for Molecular Cell Biology |
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