PINCELLI, C; FANTINI, F; ROMUALDI, P; LESA, G; GIANNETTI, A; (1991) SKIN LEVELS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN ATOPIC-DERMATITIS. ARCH DERMATOL RES , 283 (4) 230 - 232.
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Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioimmunologically in whole-tissue homogenates of lesional skin of 13 patients with atopic dermatitis. Radioimmunoassay was performed using an antiserum, AH78, recognizing the carboxy-terminal fragment vasoactive intestinal polypeptide (22-28). Vasoactive intestinal polypeptide immunoreactivity was detected in relatively low amounts in control skin (0.428 +/- 0.08 pmol/g tissue), whereas a marked increase in the peptide was observed in lesional skin of patients with atopic dermatitis (5.62 +/- 1.25 pmol/g tissue). These results seem to suggest that vasoactive intestinal polypeptide could have a pathogenetic relevance in skin lesions of atopic dermatitis.
|Title:||SKIN LEVELS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN ATOPIC-DERMATITIS|
|Keywords:||NEUROPEPTIDES, VASOACTIVE INTESTINAL POLYPEPTIDE, ATOPIC DERMATITIS, RADIOIMMUNOASSAY, SUBSTANCE-P, CUTANEOUS NERVES, SWEAT GLANDS, VIP, IMMUNOREACTIVITY, LOCALIZATION, PEPTIDE, DISEASE, CELLS, RAT|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > MRC/UCL Lab for Molecular Cell Biology|
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