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Animal models of scleroderma: lessons from transgenic and knockout mice

Derrett-Smith, EC; Denton, CP; Sonnylal, S; (2009) Animal models of scleroderma: lessons from transgenic and knockout mice. CURR OPIN RHEUMATOL , 21 (6) 630 - 635. 10.1097/BOR.0b013e32833130c1.

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Abstract

Purpose of reviewThe underlying pathogenesis of systemic sclerosis (SSc; scleroderma) involves a complex interplay of inflammation, fibrosis and vasculopathy that is incompletely understood. In this article, we highlight the important contributions that recent preclinical research has made to the knowledge base of pathogenesis and therapeutics in SSc, describe some of the newly developed models available for further investigation and discuss future research opportunities in this fascinating area.Recent findingsSeveral well characterized SSc models are available for the study of fibrosis. However, recent study on transgenic and knockout models has advanced knowledge both in fibrosis research and in vascular disease in SSc. In the present review, we focus on models in which altered signalling, particularly transforming growth factor-beta (TGF-beta), is limited to fibroblasts. We discuss contemporary models of SSc vascular disease, transgenesis in fibrocyte research, the contribution to neurological signalling research and provide examples of how preclinical models have contributed to novel therapeutics development in SSc. We also look at how research from related disciplines impacts on the SSc knowledge base.SummaryThese new models represent exciting advances. However, none completely recapitulates the vasculopathic and inflammatory components of this disease. These advances help to delineate the relative contributions of specific ligands, receptors, their signalling pathways and feedback mechanisms, in fibrotic and inflammatory processes and this will provide new targets for potential therapies in SSc.

Type: Article
Title: Animal models of scleroderma: lessons from transgenic and knockout mice
DOI: 10.1097/BOR.0b013e32833130c1
Keywords: animal models, fibrosis, scleroderma, systemic sclerosis, GROWTH-FACTOR-BETA, SYSTEMIC-SCLEROSIS, MURINE MODEL, FIBROSIS, RECEPTOR, FIBROBLASTS, MOUSE, EXPRESSION, SKIN, ACTIVATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/102619
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