UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

MAINTAINING BLOOD-FLOW IN THE EXTRACORPOREAL CIRCUIT - HEMOSTASIS AND ANTICOAGULATION

WEBB, AR; MYTHEN, MG; JACOBSON, D; MACKIE, IJ; (1995) MAINTAINING BLOOD-FLOW IN THE EXTRACORPOREAL CIRCUIT - HEMOSTASIS AND ANTICOAGULATION. INTENS CARE MED , 21 (1) 84 - 93.

Full text not available from this repository.

Abstract

Objectives: To review the methods and developments in maintaining extracorporeal circuits in critically ill patients.Design: The review includes details of the pathophysiological processes of haemostasis and coagulation in critically ill patients, methods of maintaining blood flow in the extracorporeal circuit and methods of monitoring anticoagulation agents used.Setting: Information is relevant to the management of critically ill patients requiring extracorporeal renal and respiratory support and cardiopulmonary bypass.Conclusions: Heparin is the mainstay of anticoagulation for the extracorporeal circuit although the complex abnormalities of the coagulation system in critically ill patients are associated with a considerable risk of bleeding. Alternative therapeutic agents and physical strategies (prostacyclin, low molecular weight heparin, sodium citrate, regional anticoagulation, heparin bonding and attention to circuit design) may reduce the risk of bleeding but expense and difficulty in monitoring are disadvantages.

Type: Article
Title: MAINTAINING BLOOD-FLOW IN THE EXTRACORPOREAL CIRCUIT - HEMOSTASIS AND ANTICOAGULATION
Keywords: EXTRACORPOREAL CIRCUITS, ANTICOAGULATION, HEMOSTASIS, HEPARIN, PROSTACYCLIN, CITRATE, APROTININ, VASCULAR ENDOTHELIAL-CELLS, MOLECULAR-WEIGHT HEPARIN, CRITICALLY ILL PATIENTS, CARDIOPULMONARY BYPASS, PLATELET-AGGREGATION, POLYMORPHONUCLEAR LEUKOCYTES, CITRATE ANTICOAGULATION, PROCOAGULANT ACTIVITY, ACTIVATED PLATELETS, CARDIAC-SURGERY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/102373
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item