Martin-Serrano, J; Marsh, M; (2007) ALIX catches HIV. Cell Host Microbe , 1 (1) 5 - 7. 10.1016/j.chom.2007.02.006.
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ESCRT and ESCRT-associated proteins are required during the assembly and release of many RNA viruses, including HIV. Two new papers provide structures for the ESCRT-associated protein ALIX/AIP1 and demonstrate how this protein interacts with HIV Gag. One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered.
|Title:||ALIX catches HIV.|
|Keywords:||Animals, Calcium-Binding Proteins, Carrier Proteins, Cell Cycle Proteins, Endosomal Sorting Complexes Required for Transport, Endosomes, Gene Products, gag, HIV, HIV Infections, Humans, Proteins, Virus Assembly|
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