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Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease

Chen, CC; Litvak, V; Gilbertson, T; Kuhn, A; Lu, CS; Lee, ST; Tsai, CH; ... Brown, P; + view all (2007) Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease. EXP NEUROL , 205 (1) 214 - 221. 10.1016/j.expneurol.2007.01.027.

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Abstract

Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate whether externally imposed synchronization through direct stimulation of the region of the subthalamic nucleus at 20 Hz can slow motor performance in a simple unimanual tapping task and whether this effect is frequency selective. Tapping rates were recorded on 42 sides in 22 patients with PD after overnight withdrawal of medication. Tapping was performed without stimulation and during bilateral stimulation at 20 Hz, 50 Hz and 130 Hz. We found that tapping rates were slowed by 8.2 +/- 3.2% (p=0.014) during 20-Hz stimulation in subjects with relatively preserved baseline function in the task. This effect was frequency selective. The current data provide proof of the principle that excessive beta synchrony within the basal ganglia-cortical loop may contribute to the slowing of movements in Parkinson's disease. (C) 2007 Elsevier Inc. All rights reserved.

Type: Article
Title: Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease
DOI: 10.1016/j.expneurol.2007.01.027
Keywords: synchronization, basal ganglia, Parkinson's disease, HUMAN SUBTHALAMIC NUCLEUS, DEEP BRAIN-STIMULATION, HIGH-FREQUENCY STIMULATION, OSCILLATORY ACTIVITY, CEREBRAL-CORTEX, ELECTRODES, DOPAMINE, INHIBITION, DEPENDENCY, MODULATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/102131
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