Marsh, M; McMahon, HT; (1999) The structural era of endocytosis. Science , 285 (5425) 215 - 220.
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Endocytosis is crucial for an array of cellular functions and can occur through several distinct mechanisms with the capacity to internalize anything from small molecules to entire cells. The clathrin-mediated endocytic pathway has recently received considerable attention because of (i) the identification of an array of molecules that orchestrate the assembly of clathrin-coated vesicles and the selection of the vesicle cargo and (ii) the resolution of structures for a number of these proteins. Together, these data provide an initial three-dimensional framework for understanding the clathrin endocytic machinery.
|Title:||The structural era of endocytosis.|
|Keywords:||Animals, Binding Sites, Calcium-Binding Proteins, Cell Membrane, Clathrin, Coated Pits, Cell-Membrane, Coated Vesicles, Dynamins, Endocytosis, GTP Phosphohydrolases, Membrane Proteins, Nerve Tissue Proteins, Phosphoproteins, Signal Transduction|
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