Ackland, G and Grocott, MPW and Mythen, MG (2000) Understanding gastrointestinal perfusion in critical care: so near, and yet so far. CRIT CARE , 4 (5) 269 - 281.
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An association between abnormal gastrointestinal perfusion and critical illness has been suggested for a number of years. Much of the data to support this idea comes from studies using gastric tonometry. Although an attractive technology, the interpretation of tonometry data is complex. Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete. This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.
|Title:||Understanding gastrointestinal perfusion in critical care: so near, and yet so far|
|Keywords:||gastric tonometry, sepsis, shock, splanchnic circulation, GASTRIC INTRAMUCOSAL PH, SPLANCHNIC BLOOD-FLOW, AFFERENT NERVE-STIMULATION, MESENTERIC-ARTERY FLOW, NITRIC-OXIDE SYNTHESIS, SMALL-INTESTINE, MUCOSAL ACIDOSIS, CARDIAC-SURGERY, SEPTIC SHOCK, OXYGEN-CONSUMPTION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Cardiorespiratory Sciences > ICH - Portex Anaesthesia
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