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Varicella zoster virus: review of its management

Mustafa, MB; Arduino, PG; Porter, SR; (2009) Varicella zoster virus: review of its management. J ORAL PATHOL MED , 38 (9) 673 - 688. 10.1111/j.1600-0714.2009.00802.x.

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Abstract

Varicella zoster virus (VZV) is one of eight herpes viruses known to infect humans. Primary infection causes varicella (chickenpox), after which virus becomes latent. Years later, VZV reactivates and causes a wide range of neurological diseases. The aim of the present report was to critically examine the published literature to evaluate advantages and limitations of therapy of VZV infection in both immunocompetent and immunocompromised patients. Aciclovir (ACV) has been the drug of choice for many years for the treatment of VZV infections. Recently, other antiviral agents have been developed to overcome the low oral bioavailability of ACV, as well as to provide a more flattering dosage regime. Chickenpox is a benign self-limiting disease in the majority of cases and usually no specific treatment is required. Treatment of shingles is indicated to reduce the acute symptoms of pain and malaise, to limit the spread and duration of the skin lesions and to prevent the development of post-herpetic neuralgia. Different classes of drugs have been used for the treatment of post-herpetic neuralgia. The first choice of any of these medications should be guided by the patient's medical health, the likely adverse effects of the drug and the patient's preference.

Type:Article
Title:Varicella zoster virus: review of its management
DOI:10.1111/j.1600-0714.2009.00802.x
Keywords:antiviral, oral, perioral, therapy, VZV, ACUTE HERPES-ZOSTER, PLACEBO-CONTROLLED TRIAL, RELIEVES POSTHERPETIC NEURALGIA, CONTROLLED-CLINICAL-TRIAL, LIDOCAINE PATCH 5-PERCENT, DOUBLE-BLIND TRIAL, HEALTHY-CHILDREN, ORAL ACYCLOVIR, IMMUNOCOMPROMISED PATIENTS, RANDOMIZED-TRIAL
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute

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