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Genetic control of cellular morphogenesis in Muller glia

Charlton-Perkins, M; Almeida, AD; MacDonald, RB; Harris, WA; (2019) Genetic control of cellular morphogenesis in Muller glia. GLIA , 67 (7) pp. 1401-1411. 10.1002/glia.23615. Green open access

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Abstract

Cell shape is critical for the proper function of every cell in every tissue in the body. This is especially true for the highly morphologically diverse neural and glia cells of the central nervous system. The molecular processes by which these, or indeed any, cells gain their particular cellspecific morphology remain largely unexplored. To identify the genes involved in the morphogenesis of the principal glial cell type in the vertebrate retina, the Müller glia (MG), we used genomic and CRISPR based strategies in zebrafish (Danio rerio). We identified 41 genes involved in various aspects of MG cell morphogenesis and revealed a striking concordance between the sequential steps of anatomical feature addition and the expression of cohorts of functionally related genes that regulate these steps. We noted that the many of the genes preferentially expressed in zebrafish MG showed conservation in glia across species suggesting evolutionarily conserved glial developmental pathways.

Type: Article
Title: Genetic control of cellular morphogenesis in Muller glia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/glia.23615
Publisher version: https://doi.org/10.1002/glia.23615
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Keywords: CRISPR, morphogenesis, Müller glia, transcriptome, zebrafish
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: http://discovery.ucl.ac.uk/id/eprint/10081423
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