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Dabrafenib and trametinib in BRAFV600E mutated glioma.

Brown, NF; Carter, T; Kitchen, N; Mulholland, P; (2017) Dabrafenib and trametinib in BRAFV600E mutated glioma. CNS Oncology , 6 (4) 10.2217/cns-2017-0006. Green open access

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Abstract

BRAFV600E mutations have been identified in a number of glioma subtypes, most frequently in pleomorphic xanthoastrocytoma, ganglioglioma, pilocytic astrocytoma, and epithelioid glioblastoma. Although the development of BRAF inhibitors has dramatically improved the clinical outcome for patients with BRAFV600E mutant tumors, resistance develops in a majority of patients due to reactivation of the MAPK pathway. Addition of MEK inhibition to BRAF inhibition improves survival. Here we report successful treatment of two patients with BRAFV600E mutant pleomorphic xanthoastrocytoma using the BRAF inhibitor dabrafenib in combination with the MEK inhibitor trametinib.

Type: Article
Title: Dabrafenib and trametinib in BRAFV600E mutated glioma.
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/cns-2017-0006
Publisher version: https://doi.org/10.2217/cns-2017-0006
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: anaplastic, BRAFV600E mutation, dabrafenib, glioma, pleomorphic xanthoastrocytoma, trametinib
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/10076955
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