Khedr, EM;
El Fawal, B;
Abdelwarith, A;
Nasreldein, A;
Rothwell, JC;
Saber, M;
(2019)
TMS excitability study in essential tremor: Absence of gabaergic changes assessed by silent period recordings.
Neurophysiologie Clinique
, 49
(4)
pp. 309-315.
10.1016/j.neucli.2019.05.065.
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Abstract
BACKGROUND: Essential tremor (ET) is thought to emerge from activity in a distributed cerebello-thalamo-cortical network. It has been proposed that the network goes into oscillation because of abnormal GABAergic inhibitory transmission. OBJECTIVE: To test this idea by investigating GABAergic circuitry in motor cortex using transcranial magnetic stimulation (TMS). METHODS: Motor cortex excitability was examined using TMS in 21 patients with essential tremor and in 20 control subjects. Resting and active motor threshold (RMT, AMT) and input-output curves examined corticospinal excitability. Contralateral silent period (cSP) at a different range of stimulation intensities, and the ipsilateral silent period (iSP) using a stimulus intensity of 150% RMT were used as measures of GABAergic function. RESULTS: RMT and AMT were significantly lower in patients than controls and patients had a steeper I/O curve. However, there were no significant differences in either cSP at different intensities or in iSP. CONCLUSION: We found no evidence in favour of the GABA hypothesis in ET.
| Type: | Article |
|---|---|
| Title: | TMS excitability study in essential tremor: Absence of gabaergic changes assessed by silent period recordings |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neucli.2019.05.065 |
| Publisher version: | https://doi.org/10.1016/j.neucli.2019.05.065 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Contralateral cortical silent period, Cortical excitability, Essential tremor, Input-output curve, Motor threshold, Transcallosal inhibition, Transcranial magnetic stimulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10076143 |
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