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Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants

Li, AWY; King, J; (2019) Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants. Neuroscience & Biobehavioral Reviews 10.1016/j.neubiorev.2019.05.005. (In press).

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Abstract

AIM: Spatial deficits are widely observed in normal ageing and early Alzheimer's disease. This review systematically examined neuroimaging evidence for structural and functional differences in the hippocampus (HC) associated with non-pathological age-related changes in allocentric spatial abilities. METHODS: Databases were searched to identify peer-reviewed studies on allocentric spatial processing in normal ageing including MRI or fMRI data. 15 eligible studies were reviewed after applying exclusion criteria and quality assessment. RESULTS: There was a marked deficit in allocentric spatial processing and trend towards egocentric strategies in older adults when compared to young controls or across the lifespan, associated in the majority of studies with HC volumetric changes, metabolic or microstructural indicators, and underactivity. A few studies reported no significant correlations. CONCLUSION: Findings confirm literature supporting an age-related allocentric spatial processing deficit and a shift towards egocentric strategies. A majority of studies implicated HC atrophy, microstructural/metabolic alterations or functional changes in age-related allocentric spatial impairment. More sensitive imaging techniques and ecologically valid spatial tasks are needed to detect subtle changes in the HC and brain's navigational network.

Type: Article
Title: Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants
Location: United States
DOI: 10.1016/j.neubiorev.2019.05.005
Publisher version: https://doi.org/10.1016/j.neubiorev.2019.05.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ageing, allocentric spatial processing, neuroimaging, spatial memory, spatial navigation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/10075461
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