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Associations of age and body mass index with 2 hydration and density of fat-free mass from 4 to 22 years

Wells, J; Gutierrez-Marin, D; Luque, V; Ferre, N; Fewtrell, M; Williams, J; (2019) Associations of age and body mass index with 2 hydration and density of fat-free mass from 4 to 22 years. European Journal of Clinical Nutrition , 73 pp. 1422-1430. 10.1038/s41430-019-0447-4. Green open access

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Abstract

Background: Most body composition techniques assume constant properties of fat free mass (FFM) (hydration and density) regardless of nutritional status, which may lead to biased values. Aim: To evaluate the interactive associations of age and body mass index (BMI) with hydration and density of FFM. Methods: Data from subjects aged between 4 and 22 years old from several studies conducted in London, UK were assessed. Hydration (HFFM) and density (DFFM) of FFM obtained from the four-component model in 936 and 905 individuals, respectively, were assessed. BMI was converted in to z-scores, and categorised into five groups using z-score cut-offs (thin, normal weight, overweight, obese, and severely obese). Linear regression models for HFFM and DFFM were developed using age, sex, and BMI group as predictors. Results: Nearly 30% of the variability in HFFM was explained by models including age and BMI groups, showing increasing HFFM values in heavier BMI groups. On the other hand, ∼40% of variability in DFFM was explained by age, sex, and BMI groups, with DFFM values decreasing in association with higher BMI group. Conclusion: Nutritional status should be considered when assessing body composition using two-component methods, and reference data for HFFM and DFFM is needed for higher BMI groups to avoid bias. Further research is needed to explain intra-individual variability in FFM properties.

Type: Article
Title: Associations of age and body mass index with 2 hydration and density of fat-free mass from 4 to 22 years
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41430-019-0447-4
Publisher version: https://doi.org/10.1038/s41430-019-0447-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10075356
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